Spindle fibres arise from the poles towards the centre. What is the Difference Between Aster and Spindle Fibres?Īster fibres are a variant of microtubules that arise from centrioles. Moreover, both are components of spindle apparatus.Both fibres are present in animal cells.Aster and spindle fibres are two types of fibres involved in mitosis and meiosis.What are the Similarities Between Aster and Spindle Fibres? Therefore, spindle fibres have to equally divide chromosomes into two daughter cells from a parent cell during cell division. Spindle fibres are also known as mitotic spindles during mitosis since they produce genetically identical daughter cells and meiotic spindle during meiosis since it produces gametes with half the number of chromosomes than the parent cell. They are protein structures, and they divide the genetic materials in a cell. Spindle fibres are microtubules that form the mitotic and meiotic spindle during cell division. The orientation of aster fibres determines the plane of division of cells during cell division. The spindle fibres move chromosomes to the centre during metaphase. The nuclear envelope separates into fragments, and mitotic spindles form during pro-metaphase. Thus, the aster fibres organize the spindle fibres, which extend from both poles and the fibres that attach to chromosomes at the kinetochores. The two centrosomes with asters migrate to the opposite sides of the nucleus to form mitotic spindles. Aster fibres pull half of the genetic information to each side of the nucleus during the process therefore, the nucleus divides in half, leaving two daughter nuclei.Īster fibres initially appear during prophase in cell division. They help the chromosomes to line up and arrange in the centre of the nucleus. The fibres provide support to the chromosomes to guide them to end up in the right place during cell division. Microtubules make up the Aster rays, and they radiate from the centrosome. Aster fibres are made up of microtubules and are a part of the cytoskeleton. Summary – Aster vs Spindle Fibres What are Aster Fibres?Īster fibres are star-shaped cellular structures that consist of a centrosome and are associated with microtubules during early mitotic and meiotic stages in animal cells. Aster vs Spindle Fibres in Tabular FormĦ. Similarities – Aster and Spindle Fibresĥ. Aster fibres and spindle fibres are microtubules. In animal cells, they are made of microtubule arrays. Spindle apparatus is made of spindle fibres, motor proteins, and chromosomes. Both are components of spindle apparatus. Therefore, although both anti-mitotic spindle apparatus antibodies are not associated to a defined autoimmune pathology, the presence of NuMA antibodies, mainly at high titers, may be an indication for a more extensive screening of CTD.The key difference between aster and spindle fibres is that aster fibres are formed around the centrioles and project out towards the pole, while spindle fibres arise from the pole towards the centre.Īster fibres and spindle fibres are essential for cell divisions: mitosis and meiosis. Seven patients (17.5%) were diagnosed with different organ-specific autoimmune diseases, whereas in the other 15 patients (37.5%), no autoimmune pathology could be documented. NuMA positivity associated with a diagnosis of connective tissue disease (CTD) in 18 patients (45%), primary Sjögren or sicca syndrome and undifferentiated connective tissue disease being the most represented. NuMA reactivity was further confirmed by immunoblotting.Īntibodies to HsEg5 did not associate with any specific pathology. We have analysed the clinical data of 40 anti-NuMA- (0.87 per thousand) and 7 anti-HsEg5- (0.15 per thousand) positive patients detected during routine immunofluorescence examination of 45,804 sera. The clinical associations of NuMA and HsEg5 antibodies, the main anti-mitotic spindle apparatus autoantibodies, remain unclear due to their extremely low prevalence.
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